Global immune disregulation in multiple sclerosis: from the adaptive response to the innate immunity.
J Neuroimmunol
; 107(2): 216-9, 2000 Jul 24.
Article
em En
| MEDLINE
| ID: mdl-10854659
ABSTRACT
Increasing evidences show a global immune disregulation in multiple sclerosis (MS). The possible involvement of myelin and non-myelin (auto-)antigens in the autoaggressive process as well as the disregulation of both adaptive and innate immunity challenge the concept of specific immunotherapy. T cells at the boundary between innate and adaptive immunity, whose immunoregulatory role is becoming increasingly clear, have recently been shown to bear relevance for MS pathogenesis. Global immune interventions (and type I interferons may be considered as such) aimed at interfering with both innate and acquired immune responses seem to be a most promising therapeutic option in MS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuroimunomodulação
/
Sistema Imunitário
/
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Itália