Role of self-carriers in the immune response and tolerance. I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells.
J Exp Med
; 144(5): 1369-74, 1976 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-1086885
ABSTRACT
Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells,but go on to generate cytotoxic T cells directed at hapten-modified H-2.These results suggest that hapten-modifeid spleen cells may differentially induce B-cell tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trinitrobenzenos
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Linfócitos B
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Linfócitos T
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Tolerância Imunológica
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Imunidade Celular
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Formação de Anticorpos
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Nitrobenzenos
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1976
Tipo de documento:
Article