Use of Tc-99m HMPAO leukocyte scans to evaluate bone infection: incremental value of additional SPECT images.
Clin Nucl Med
; 25(7): 519-26, 2000 Jul.
Article
em En
| MEDLINE
| ID: mdl-10885693
ABSTRACT
PURPOSE:
In this study, the diagnostic value of Tc-99m hexamethylpropylene amine oxime (HMPAO) leukocyte scans and the role of additional SPECT in the diagnosis of bone infection were evaluated. MATERIALS ANDMETHODS:
The Tc-99m HMPAO leukocyte scans of 37 patients with clinically suspected bone infection were reviewed. The patients were divided into two groups according to the presence of orthopedic implants. Early (4 to 6 hours) and delayed (18 to 20 hours) planar images and early SPECT images were obtained. The final diagnosis of infection was made based on the pathologic, bacteriologic, and surgical data and clinical follow-up.RESULTS:
Group 1 (25 patients with orthopedic implants) included 15 true-positive, 1 false-negative, 7 true-negative, and 2 false-positive results. Group 2 (12 patients without orthopedic implants) included 7 true-positive, 1 false-negative, and 4 true-negative results. The overall sensitivity of the Tc-99m HMPAO leukocyte scan with SPECT to detect bone infection was 92%, with a specificity rate of 85%. (Group 1 sensitivity, 94%; specificity, 78%. Group 2 88% and 100% sensitivity and specificity, respectively.)CONCLUSION:
The Tc-99m HMPAO leukocyte scan is useful in the diagnosis of bone infection, regardless of the presence of orthopedic implants. The additional SPECT images may be helpful to localize the site of infection more accurately.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteomielite
/
Tomografia Computadorizada de Emissão de Fóton Único
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Compostos Radiofarmacêuticos
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Tecnécio Tc 99m Exametazima
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Revista:
Clin Nucl Med
Ano de publicação:
2000
Tipo de documento:
Article