[Effect of iodine application during radioiodine therapy in patients with impending therapy failure]. / Einfluss einer lodidgabe während der Radioiodtherapie bei Patienten mit drohendem Therapieversagen.
Nuklearmedizin
; 39(4): 108-12, 2000.
Article
em De
| MEDLINE
| ID: mdl-10919161
ABSTRACT
AIM:
We investigated whether additional application of "cold" iodine after therapy with radioiodine could result in a prolongation of the effective half life of iodine-131 and would thus lead to an increase of the effective thyroid radiation dose.METHODS:
Time-activity-curves after therapy with radioiodine were analysed in 25 patients (16 women, 9 men). Nine patients suffered from autonomously functioning thyroid nodules, 5 from autonomous multinodular goiter and 11 from Graves' disease. These patients had an effective half life shorter than 4 days resulting in an undertreatment of > 20% with respect to the desired effective thyroid radiation dose. 2-4 days after therapy with radioiodine all patients received "cold" iodine for three days in a dose of 3 x 200 micrograms per day.RESULTS:
In 14 of the 25 patients an increase of the effective half life was observed. Patients with an autonomously functioning thyroid nodule showed a mean increase of the effective thyroid radiation dose of 40 +/- 44 Gy, patients with toxic multinodular goiter of 29 +/- 30 Gy and patients with Graves' disease of 37 +/- 37 Gy.CONCLUSION:
Additional application of "cold" iodine after therapy with radioiodine can prolong the effective half life in selected patients. We suspect a correlation with the thyroid iodine pool. This will be the basis for further investigations hopefully resulting in a better patient preselection to determine who might respond to this therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Graves
/
Nódulo da Glândula Tireoide
/
Bócio Nodular
/
Iodo
/
Radioisótopos do Iodo
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Nuklearmedizin
Ano de publicação:
2000
Tipo de documento:
Article