Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences.
Science
; 204(4397): 1087-8, 1979 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-109919
ABSTRACT
In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Imunoglobulinas
/
Proteínas do Mieloma
/
Regiões Constantes de Imunoglobulina
/
Cadeias Pesadas de Imunoglobulinas
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1979
Tipo de documento:
Article