The HFE gene undergoes alternate splicing processes.
Blood Cells Mol Dis
; 26(2): 155-62, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-11001625
ABSTRACT
The MHC class I-related HFE gene appears to be involved in iron metabolism, but its pathogenic mechanism in hemochromatosis remains unknown. Furthermore, very little is known about the regulation of its expression. Hybridization of human tissue Northern blots revealed five different HFE mRNAs, indicating that HFE gene transcription is subject to alternative processes. cDNA selection and RT-PCR performed on HeLa cells clearly demonstrated the occurrence of either differential termination or splicing in HFE transcription. Among the numerous molecules identified, two may have a genuine biological significance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genes MHC Classe I
/
Antígenos de Histocompatibilidade Classe I
/
Processamento Alternativo
/
Antígenos HLA
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Revista:
Blood Cells Mol Dis
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
França