Zaleplon and triazolam physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons.
Drug Alcohol Depend
; 61(1): 69-84, 2000 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-11064185
ABSTRACT
The ability of the GABA(A)-receptor-subtype-selective hypnotic zaleplon to produce physical dependence was compared to the nonselective benzodiazepine triazolam. Progressively increasing doses of zaleplon and triazolam were given to baboons by intragastric infusion once each day, with doses increasing every 17 days. Next, the highest dose was given for 10-34 additional days by continuous infusion. Both drugs produced increases in food-maintained lever pressing, ataxia, and time to complete a fine motor task. Plasma levels increased dose-dependently; drug was detectable 24 h after higher doses. Flumazenil produced a mild or intermediate precipitated-withdrawal syndrome on day 14 of all dosing conditions. When drug delivery ended after 85-100 days, a benzodiazepine-type withdrawal syndrome occurred. Physical dependence potential of zaleplon and triazolam appear similar.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Triazolam
/
Moduladores GABAérgicos
/
Transtornos Relacionados ao Uso de Substâncias
/
Hipnóticos e Sedativos
/
Acetamidas
Limite:
Animals
Idioma:
En
Revista:
Drug Alcohol Depend
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos