Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay.
Math Biosci
; 169(1): 27-51, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11137527
ABSTRACT
A stochastic model for the in vivo micronucleus assay is presented. This model describes the kinetic of the rate of micronucleated polychromatic erythrocytes induced by the administration of a mutagenic compound. For this, biological assumptions are made both on the erythropoietic system and on the mechanisms of action of the compound. Its pharmacokinetic profile is also taken into account and it is linked to the induced toxicological effect. This model has been evaluated by analyzing the induction of micronuclei is mice bone marrow by a mutagenic compound, 6-mercaptopurine (6-mp). This analysis enabled to make interesting remarks about the induction of micronuclei by 6-mp and to put to light an unsuspected wavy kinetic by optimizing the experimental design of the in vivo micronucleus assay.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes para Micronúcleos
/
Modelos Biológicos
/
Mutagênicos
Tipo de estudo:
Health_economic_evaluation
Limite:
Animals
Idioma:
En
Revista:
Math Biosci
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
França