Inhalation carcinogenicity of alpha halo ethers. II. Chronic inhalation studies with chloromethyl methyl ether.
Arch Environ Health
; 30(2): 70-2, 1975 Feb.
Article
em En
| MEDLINE
| ID: mdl-1115530
ABSTRACT
Rats and hamsters were exposed to 1 ppm of chloromethyl methyl ether six hours per day, five days per week, throughout their lifetime. Mortality and weight gain of the exposed animals paralleled that of the control animals. Malignant tumors of the respiratory tract were found in two rats. These were a squamous cell carcinoma of the lung with blood vessel invasion and an esthesloneuroepithelioma originating in the olfactory epithelium and invading the forebrain. One hamster was found to have an adenocarcinoma of the lung and another, a squamous papilloma of the trachea. A single exposed rat had a pituitary tumor of primitive cell type that may well have been coincidental.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Sistema Respiratório
/
Carcinógenos
/
Cloreto de Metila
/
Éteres Metílicos
Limite:
Animals
Idioma:
En
Revista:
Arch Environ Health
Ano de publicação:
1975
Tipo de documento:
Article