PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.
Trends Biochem Sci
; 26(1): 30-5, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11165514
ABSTRACT
Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monoéster Fosfórico Hidrolases
/
Frutosedifosfatos
/
Fígado
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos