Homocyst(e)ine, oxidative stress, and endothelium function in uremic patients.
Kidney Int Suppl
; 78: S243-5, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11169019
ABSTRACT
Moderate hyperhomocyst(e)inemia and impaired endothelium-dependent vasodilatation are present in uremic patients. However, the precise mechanism(s) underlying the link between moderate hyperhomocyst(e)inemia and endothelium dysfunction in uremic patients remains to be determined. Experimental and clinical evidence have led to the suggestion that moderate hyperhomocyst(e)inemia may predispose to endothelium dysfunction through a mechanism that involves generation of reactive oxygen species and a decrease in nitric oxide bioavailability. Recent preliminary findings in uremic patients provide support for some aspects of this suggestion. These data must be confirmed in additional studies. Moreover, the relative importance of homocysteine-induced oxidant stress versus other potential mechanisms of endothelium dysfunction in these patients remains to be determined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uremia
/
Endotélio Vascular
/
Homocisteína
/
Homocistina
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Kidney Int Suppl
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
França