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Nephron induction--the epithelial mesenchymal interface revisited.
Strehl, R; Minuth, W W.
Afiliação
  • Strehl R; Department of Anatomy, University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.
Pediatr Nephrol ; 16(1): 38-40, 2001 Jan.
Article em En | MEDLINE | ID: mdl-11198601
ABSTRACT
While more and more humoral factors are being implicated in nephrogenesis, there is no detailed knowledge of the morphological structures at the interface of the nephron inducer and the surrounding mesenchyme. Hence we examined this area in the cortex of neonatal rabbit kidneys by scanning and transmission electron microscopy. Our interest was focused on the basal aspect of the collecting duct ampulla and the surrounding competent mesenchyme where morphogenic signals are exchanged during nephron induction. Close contact between these two tissues is assumed during nephrogenesis to allow direct cellular contact or diffusion of soluble factors across a short distance. However, our data show the presence a wide cleft around the collecting duct ampulla spatially separating the inducer and the competent mesenchyme during nephron induction. This cleft is filled with a characteristic fibrillar mesh-work.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Animais Recém-Nascidos / Néfrons Limite: Animals Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Animais Recém-Nascidos / Néfrons Limite: Animals Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Alemanha