Effects of preterm infant formula supplementation with alpha-linolenic acid with a linoleate/alpha-linolenate ratio of 6: a multicentric study.
Eur J Clin Nutr
; 51(8): 520-6, 1997 Aug.
Article
em En
| MEDLINE
| ID: mdl-11248877
ABSTRACT
OBJECTIVE:
To investigate the effects of a milk formula supplemented with a alpha-linolenic acid (ALA) (182 n-6/183 n-3 ratio near 6/1) on plasma and red blood cell (RBC) fatty acids (FAs) in premature infants and compare with a non supplemented formula (182 n-6/183 n-3 = 22/1). DESIGN ANDSUBJECTS:
Infants of mothers who elected not to breast-feed were randomly assigned to either a high alpha linolenic formula (HLF n = 31) group or a low alpha-linolenic formula (LLF n = 32) control group. Infants fed human milk (HM n = 25) were enrolled concurrently as a reference group. Anthropometric and biological measurements were made after two days (D2) and 15 d (D15) of enteral feeding and at the 37th week (W37) of postconceptual age. In HLF, the 183 n-3 content was 1.95% of total FAs (0.77% of total energy) and the 182 n-6/183 n-3 ratio was near 6/1. In LLF, the 183 n-3 content was 0.55% of total FAs (0.22% of total energy) and the 182 n-6/183 n-3 ratio was 22/1.RESULTS:
ALA supplementation had minimal effect on the n-6 series, did not alter the anthropometric data and confirmed the conversion of ALA into docosahexaenoic acid (DHA). Throughout the study, it maintained, the RBC membrane DHA values within the confidence interval of those obtained in the HM group. Such was not the case with LLFCONCLUSION:
alpha-linolenic acid supplementation (from Rapeseed oil and in a 182 n-6/183 n-3 ratio = 6) in premature infant formula can contribute efficiently to the maintenance of the n-3 status in the premature newborns.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Ácido alfa-Linolênico
/
Ácidos Graxos
/
Alimentos Infantis
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Eur J Clin Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França