3-Desoxyanthocyanidins from Arrabidaea chica.
Phytochemistry
; 56(8): 831-5, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11324913
ABSTRACT
The new 3-desoxyanthocyanidins 6,7,3'-trihydroxy-5,4'-dimethoxy-flavylium and 6,7,3',4'-tetrahydroxy-5-methoxy-flavylium and the known 6,7-dihydroxy-5,4'-dimethoxy-flavylium (Carajurin) were isolated by bioguided fractionation from the leaves of Arrabidaea chica, with transcription factor NF-kappaB as target. The structure of Carajurone was revised to be 6,7,4'-trihydroxy-5-methoxy-flavylium. Additionally, the flavone acacetin was found. All structures were mainly established on the basis of MS- and NMR data (1H, 1H-1H COSY and partly 13C, GHMQCR and GHSQCR). Carajurin, which failed to give a positive result in the DPPH TLC assay completely inhibited NF-kappaB, but not NF-AT at a 500 microM concentration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xantenos
/
Magnoliopsida
/
Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha