2-(3,5-Dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor.
Bioorg Med Chem Lett
; 11(8): 1073-6, 2001 Apr 23.
Article
em En
| MEDLINE
| ID: mdl-11327593
ABSTRACT
A series of 2-(3,5-dimethylphenyl)tryptamine derivatives was prepared and evaluated on a rat gonadotropin releasing hormone receptor assay. Some para-substituents on the 4-phenylbutyl side chain attached to the tryptamine nitrogen led to compounds with potent GnRH receptor binding. The study has helped define structural requirements for GnRH receptor binding for the 2-aryltryptamine GnRH antagonists.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triptaminas
/
Receptores LHRH
/
Antagonistas de Hormônios
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos