Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding.
Diabetes
; 50(5): 1206-10, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11334428
ABSTRACT
Neuropeptide Y (NPY), one of the most abundant peptide transmitters in the mammalian brain, is assumed to play an important role in feeding and body weight regulation. However, there is little genetic evidence that overexpression or knockout of the NPY gene leads to altered body weight regulation. Previously, we developed NPY-overexpressing mice by using the Thy-1 promoter, which restricts NPY expression strictly within neurons in the central nervous system, but we failed to observe the obese phenotype in the heterozygote. Here we report that in the homozygous mice, overexpression of NPY leads to an obese phenotype, but only after appropriate dietary exposure. NPY-overexpressing mice exhibited significantly increased body weight gain with transiently increased food intake after 50% sucrose--loaded diet, and later they developed hyperglycemia and hyperinsulinemia without altered glucose excursion during 1 year of our observation period.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Neuropeptídeo Y
/
Encéfalo
/
Sacarose Alimentar
/
Obesidade
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Diabetes
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão