Activation of the HIF pathway in cancer.
Curr Opin Genet Dev
; 11(3): 293-9, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11377966
ABSTRACT
The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common cancers. This occurs both by genetic mechanisms and through microenvironmental hypoxia. Activation of the HIF pathway has important effects on patterns of gene expression in tumours.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Nucleares
/
Transdução de Sinais
/
Transativadores
/
Proteínas de Ligação a DNA
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Reino Unido