A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier.
Science
; 292(5522): 1722-5, 2001 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-11387478
ABSTRACT
Listeria monocytogenes is responsible for severe food-borne infections, but the mechanisms by which bacteria cross the intestinal barrier are unknown. Listeria monocytogenes expresses a surface protein, internalin, that interacts with a host receptor, E-cadherin, to promote entry into human epithelial cells. Murine E-cadherin, in contrast to guinea pig E-cadherin, does not interact with internalin, excluding the mouse as a model for addressing internalin function in vivo. In guinea pigs and transgenic mice expressing human E-cadherin, internalin was found to mediate invasion of enterocytes and crossing of the intestinal barrier. These results illustrate how relevant animal models for human infections can be generated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Caderinas
/
Enterócitos
/
Proteínas Supressoras de Tumor
/
Modelos Animais de Doenças
/
Listeriose
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Listeria monocytogenes
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Proteínas de Neoplasias
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Proteínas do Tecido Nervoso
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
França