Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
Science
; 293(5534): 1495-9, 2001 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-11520989
ABSTRACT
In mammals, the canonical nuclear factor kappaB (NF-kappaB) signaling pathway activated in response to infections is based on degradation of IkappaB inhibitors. This pathway depends on the IkappaB kinase (IKK), which contains two catalytic subunits, IKKalpha and IKKbeta. IKKbeta is essential for inducible IkappaB phosphorylation and degradation, whereas IKKalpha is not. Here we show that IKKalpha is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-kappaB target genes, and processing of the NF-kappaB2 (p100) precursor. IKKalpha preferentially phosphorylates NF-kappaB2, and this activity requires its phosphorylation by upstream kinases, one of which may be NF-kappaB-inducing kinase (NIK). IKKalpha is therefore a pivotal component of a second NF-kappaB activation pathway based on regulated NF-kappaB2 processing rather than IkappaB degradation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Transdução de Sinais
/
NF-kappa B
/
Proteínas Serina-Treonina Quinases
/
Tecido Linfoide
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos