Torsades de pointes due to drug interaction between disopyramide and clarithromycin.
Heart Dis
; 1(4): 206-7, 1999.
Article
em En
| MEDLINE
| ID: mdl-11720625
ABSTRACT
Torsades de pointes (TdP) is polymorphic ventricular tachycardia occurring in the setting of a prolonged cardiac repolarization. Drug interactions between macrolide antibiotics such as erythomycin and pharmacologic agents that prolong the QT interval have been known to cause TdP. However, clarithromycin is thought to be less frequently associated with drug induced TdP, because it inactivates hepatic cytochrome P-450 to a lesser extent than erythromycin. We describe a case of TdP caused by a drug interaction in a 76-year-old woman taking long-term disopyramide after she was given clarithromycin concomitantly for chronic bronchitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Torsades de Pointes
/
Claritromicina
/
Disopiramida
/
Antiarrítmicos
/
Antibacterianos
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Heart Dis
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos