Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression.
Am J Psychiatry
; 158(12): 2074-6, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11729031
ABSTRACT
OBJECTIVE:
Depression has been associated with increased platelet activation. Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype.METHOD:
Elderly subjects with (N=61) and without (N=12) major depression were assessed for cognitive impairment, cardiovascular disease, and two indices of platelet activation. The depressed subjects were genotyped for the 5-HTTLPR polymorphism.RESULTS:
The depressed subjects were older, were more cognitively impaired, and had higher platelet factor 4 and beta-thromboglobulin levels; cardiovascular disease was minimal in both groups. In the depressed group, subjects with the 5-HTTLPR l/l genotype had significantly higher platelet factor 4 and beta-thromboglobulin levels.CONCLUSIONS:
Platelet activation is increased in elderly depressed patients, especially those with the 5-HTTLPR l/l genotype. This finding suggests how genetic differences may influence cardiovascular mortality in depressed patients with ischemic heart disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Polimorfismo Genético
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Ativação Plaquetária
/
Regiões Promotoras Genéticas
/
Transtorno Depressivo Maior
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos