The baboon (Papio anubis) extracranial carotid artery: an anatomical guide for endovascular experimentation.
BMC Cardiovasc Disord
; 1: 4, 2001.
Article
em En
| MEDLINE
| ID: mdl-11747471
ABSTRACT
BACKGROUND:
As novel endovascular strategies are developed for treating neurological disease, there is an increasing need to evaluate these techniques in relevant preclinical models. The use of non-human primates is especially critical given their structural and physiological homology with humans. In order to conduct primate endovascular studies, a comprehensive understanding of the carotid anatomy is necessary. We therefore performed a detailed examination of the vessel lengths, lumen diameters and angles of origin of the baboon extracranial carotid system.METHODS:
We characterized the extracranial carotid system often male baboons (Papio anubis, range 15.1-28.4 kg) by early post-mortem dissection. Photographic documentation of vessel lengths, lumen diameters, and angles of origin were measured for each segment of the carotid bilaterally.RESULTS:
The common carotid arteries averaged 94.7 +/- 1.7 mm (left) and 87.1 +/- 1.6 mm (right) in length. The average minimal common carotid lumen diameters were 3.0 +/- 0.3 mm (left) and 2.9 +/- 0.2 mm (right). Each animal had a common brachiocephalic artery arising from the aorta which bifurcated into the left common carotid artery and right braciocephalic artery after 21.5 +/- 1.6 mm. The vascular anatomy was found to be consistent among animals despite a wide range of animal weights.CONCLUSIONS:
The consistency in the Papio anubis extracranial carotid system may promote the use of this species in the preclinical investigation of neuro-interventional therapies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papio
/
Artérias Carótidas
/
Modelos Animais
Limite:
Animals
Idioma:
En
Revista:
BMC Cardiovasc Disord
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos