Levels of GM-CSF, IL-3, and IL-6 in fluid and tissue from human radicular cysts.
J Dent Res
; 81(1): 64-8, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11824415
ABSTRACT
Cytokines released by immune system cells play an important role in cyst enlargement. This study aimed to determine, by ELISA, the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), and IL-6 in fluid and tissue from human radicular cysts. GM-CSF was found in 42.8% of the fluid samples (164.3 pg/mL) and IL-6 in 92.8% (641.4 pg/mL). No IL-3 was detected in any fluid samples. In the tissue samples, 28.6% were positive for IL-3 (369.2 pg/mL), 86.4% for IL-6 (92.4 pg/mL), and 95.8% for GM-CSF (200.5 pg/mL). It can be concluded that GM-CSF and IL-6 were widely found in the fluid and tissue samples. In contrast, IL-3 was found only in the cystic tissue, even though in few lesions. These cytokines may contribute to the inflammation, cystic growth, and bone resorption that characterize cystic lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cisto Radicular
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Interleucina-6
/
Interleucina-3
/
Líquido Cístico
Limite:
Humans
Idioma:
En
Revista:
J Dent Res
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil