[The role of endothelins in human cardiovascular disease]. / Udzial endotelin w schorzeniach ukladu krazenia.
Pol Merkur Lekarski
; 11(65): 444-6, 2001 Nov.
Article
em Pl
| MEDLINE
| ID: mdl-11852820
ABSTRACT
Endothelin-1 was first identified by Yanagisawa in 1988 and shown to be a potent and sustained vasoconstrictor and pressure peptide. Endothelial cells line all blood vessels and are capable of generating endothelin-1; receptors for the endothelins are widely expressed, particularly in tissues involved in cardiovascular regulation, including the heart, blood vessels, kidney and brain. Endothelin-1 has potent vasoconstrictor properties and the coronary, renal and cerebral blood vessels appear particularly sensitive. Moreover, endothelin-1 has activity as co-mitogen, interacts with the sympathetic nervous and renin-angiotensin system. These properties indicate a likelihood that the endothelin system is of functional importance in human cardiovascular physiology and may play a role in the pathophysiology of cardiovascular disease. It is possible that endothelin antagonists might be effective in the treatment of diseases associated with intermittent or sustained vasoconstriction.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Endotelinas
/
Receptores de Endotelina
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Pl
Revista:
Pol Merkur Lekarski
Assunto da revista:
MEDICINA
Ano de publicação:
2001
Tipo de documento:
Article