Signaling pathways activated by chemokine receptor CXCR2 and AMPA-type glutamate receptors and involvement in granule cells survival.
J Neuroimmunol
; 123(1-2): 9-17, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11880144
ABSTRACT
We show that treatment of cerebellar granules with interleukin-8 (IL-8), growth-related gene product beta (GRObeta) or AMPA induced activation of PI3-K/Akt and of ERK pathways, the latter being independent of PI3-K and dependent on PTX-sensitive G proteins. We also show that AMPA-mediated neuron survival was abolished both by ERK kinase inhibitor PD98059 and AMPA-Rs blocker CNQX, and that chemokine-mediated survival was blocked by the PI3-K inhibitors LY294002 and wortmannin. We conclude that the neurotrophic effects of AMPA need the contemporary activation of ERKs and stimulation of AMPA-Rs, and that PI3-K/Akt activation is a determinant pathway for the IL-8/GRObeta anti-apoptotic activity.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Cerebelo
/
Proteínas Serina-Treonina Quinases
/
Receptores de AMPA
/
Quimiocinas CXC
/
Receptores de Interleucina-8B
/
Peptídeos e Proteínas de Sinalização Intercelular
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Itália