Interferon beta in multiple sclerosis: relationship between sustained serum IgG levels and clinical outcome.
J Neuroimmunol
; 129(1-2): 232, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12161040
ABSTRACT
We investigated the effects of interferon beta-1a (IFN beta-1a) on specific response towards two immunodominant MBP peptides and on global production of IgG. We evaluated 54 sera from multiple sclerosis (MS) patients at baseline and 1 year after treatment. We did not observe any modification of immune response to the MBP peptides but we noted a significant decrease in mean IgG concentrations in patients with progression of the disease but not in stable patients. These results suggest that IFN beta1a restores or maintains a beneficial immune response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Regulação para Baixo
/
Interferon beta
/
Sistema Imunitário
/
Esclerose Múltipla
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
França