Effects of urethane on hippocampal unit activity in the rat.
Brain Res Bull
; 3(5): 567-70, 1978.
Article
em En
| MEDLINE
| ID: mdl-122723
ABSTRACT
The effect of urethane on hippocampal single unit activity in rats paralyzed with gallamine triethiodide was examined to determine possible influences of urethane as an anesthetic for electrophysiological recordings. With intravenous injections of urethane (1.0 g/kg body weight), hippocampal units responded initially with a substantial decrease in spontaneous firing rate. Activity in some cells recovered partially after a period of approximately 45 min. The activity of the remainder of cells recorded remained depressed for periods of time up to 1.5 hr. Longer periods of depression were observed in some cells. The difference in susceptibility to urethane in the population of hippocampal cells may offer a selective alteration in patterns of spontaneous activity in the hippocampus and systems efferent to the hippocampus. A knowledge of such alterations may prove important in interpreting the results of electrophysiological recording in preparations under urethane anesthesia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uretana
/
Hipocampo
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
1978
Tipo de documento:
Article