Calcium and the failing heart: phospholamban, good guy or bad guy?
Sci STKE
; 2003(180): pe15, 2003 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-12721389
In cardiac cells, phospholamban is a potent inhibitor of sarcoplasmic reticulum calcium (Ca(2+)) transport. Overexpression of mutant forms of phospholamban may result in beneficial or detrimental effects on intracellular Ca(2+) handling and cardiac systolic and diastolic function. Mutations in phospholamban have also been linked to human cardiomyopathies, providing important insights into the underlying disease mechanisms and the key role of phospholamban in myocardial excitation-contraction coupling. This Perspective discusses new advances in our understanding of the role of phospholamban in intracellular Ca(2+) handling and the development of human and murine cardiomyopathies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao Cálcio
/
Cálcio
/
Insuficiência Cardíaca
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Sci STKE
Assunto da revista:
CIENCIA
/
FISIOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Alemanha