A survey of the Predictive Toxicology Challenge 2000-2001.
Bioinformatics
; 19(10): 1179-82, 2003 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-12835259
ABSTRACT
MOTIVATION The Predictive Toxicology Challenge (PTC) was initiated to stimulate the development of advanced techniques for predictive toxicology models. The goal of this challenge was to compare different approaches for the prediction of rodent carcinogenicity, based on the experimental results of the US National Toxicology Program (NTP). RESULTS:
111 sets of predictions for 185 compounds have been evaluated on quantitative and qualitative scales to select the most predictive models and those with the highest toxicological relevance. The accuracy of the submitted predictions was between 25 and 79 %. An evaluation of the most accurate models by toxicological experts showed, that it is still hard for domain experts to interpret the submitted models and to put them into relation with toxicological knowledge.AVAILABILITY:
PTC details and data can be found at http//www.predictive-toxicology.org/ptc/.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxicologia
/
Carcinógenos
/
Testes de Carcinogenicidade
/
Bases de Dados Factuais
/
Medição de Risco
/
Modelos Biológicos
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Animals
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Alemanha