Gold concentrations in blood fractions of patients with rheumatoid arthritis treated with Myocrisin.
J Pharm Biomed Anal
; 10(9): 639-44, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1286129
ABSTRACT
Gold levels in the plasma and blood cells of patients treated with the gold drug Myocrisin (sodium aurothiomalate) were determined by atomic absorption spectrometry. There is a correlation between whole blood gold and plasma gold concentrations which is different for smokers and non-smokers. Most cellular gold is associated with the membrane and is present in concentrations approximately equivalent to the number of reactive sulphydryl groups on the exofacial surface of the cell. Since gold would be expected to react with SH groups and since these groups are vital for cellular function, a possible role for gold in modifying cellular metabolism is indicated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Tiomalato Sódico de Ouro
/
Ouro
Limite:
Humans
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Nigéria