Chemical synthesis, growth-promoting activity, and metabolism of all-trans retinyl beta-glucose in the rat.
Int J Vitam Nutr Res
; 62(4): 298-302, 1992.
Article
em En
| MEDLINE
| ID: mdl-1291531
ABSTRACT
Reaction of all-trans retinol with alpha-D-glucopyranosyl bromide tetrabenzoate in the presence of silver carbonate gave all-trans retinyl beta-glucose in good yield. Depending on the mode of administration, retinyl beta-glucose, which is soluble in water, showed 67-100% of the growth-promoting activity of retinyl acetate in vitamin A-deficient rats. In metabolic studies on vitamin A-deficient rats, retinyl beta-glucose was rapidly hydrolyzed to retinol. The possible therapeutic uses of retinyl glucose are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina A
/
Deficiência de Vitamina A
/
Substâncias de Crescimento
/
Glucosídeos
Limite:
Animals
Idioma:
En
Revista:
Int J Vitam Nutr Res
Ano de publicação:
1992
Tipo de documento:
Article