[Progressive multifocal leukoencephalopathy in a female patient with chronic lymphatic leukemia]. / Progressieve multifocale leuko-encefalopathie bij een patiënte met chronische lymfatische leukemie.

ABSTRACT

This case report describes a 78-year old female patient with chronic lymphocytic leukaemia and neurological symptoms due to progressive multifocal leukoencephalopathy (PML). At autopsy the histopathology was characteristic, the involvement of JC virus was established. PML occurs in immunocompromised patients and is caused by infection with JC papova virus. Epidemiology, clinical course, diagnostic procedures with special reference to the use of the polymerase chain reaction, and therapy are briefly reviewed.