Endocrine effects of human recombinant interleukin-3 in cancer patients.
Int J Biol Markers
; 7(4): 230-3, 1992.
Article
em En
| MEDLINE
| ID: mdl-1337088
ABSTRACT
It is known that several cytokines can exert hormonal effects. At present, no data are available about the possible influence of IL-3 on the endocrine system. In order to investigate the endocrine effects of IL-3 in humans, we have evaluated serum levels of cortisol, beta-endorphin, GH, PRL, FSH, LH, TSH and melatonin in response to intravenous injection of IL-3 at a dose of 1 mcg/kg b.w. at 6.00 p.m. The study was performed in 5 non-small cell lung cancer patients. GH increased significantly in response to IL-3. PRL showed a progressive decrease after IL-3 injection, but its variations were not statistically significant. All other hormones, including cortisol, were not affected by IL-3. This preliminary study shows that IL-3 may exert endocrine effects in humans, which would seem at variance with previously reported results on most other cytokines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interleucina-3
/
Carcinoma Pulmonar de Células não Pequenas
/
Glândulas Endócrinas
/
Neoplasias Pulmonares
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Biol Markers
Assunto da revista:
BIOQUIMICA
/
NEOPLASIAS
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália