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Dopamine receptor antagonists increase markedly the quantity of retrograde transport of HRP in the rat masseteric motoneuron.
Kawagishi, S; Yoshino, K; Jones, T E; Iwamoto, M; Arai, S; Amano, N.
Afiliação
  • Kawagishi S; Department of Oral Neuroscience, Kyushu Dental College, Kitakyushu, Japan.
Brain Res ; 585(1-2): 196-204, 1992 Jul 10.
Article em En | MEDLINE | ID: mdl-1355002
ABSTRACT
Horseradish peroxidase (HRP) was injected, bilaterally, into the rat masseter muscle, subsequent to an intramuscular or intraperitoneal injection of one of five dopamine antagonists (chlorpromazine and haloperidol as the D1 and D2 receptor antagonist, SCH 23390 as the specific D1 receptor antagonist, sulpiride and domperidone as the specific D2 receptor antagonist). Control rats received an injection of a corresponding vehicle solution. After a survival period of 16 h, the brainstem was cut into 60 microns cryosections and processed with the TMB technique. The amount of retrogradely transported HRP was quantitatively measured in terms of the amount of HRP reaction product present in the motoneuron by the method which we have developed using an image processing system combined with a light microscope and a TV camera. Chlorpromazine, haloperidol, SCH 23390 and sulpiride significantly raised the quantity of retrograde transport of HRP. On the contrary, domperidone which can not penetrate the blood-brain barrier showed no significant change in the amount of the retrograde transport. In addition, an intravenous injection of chlorpromazine (8 mg/kg) was found to increase the amplitude of monosynaptic masseteric reflex EMG activity evoked by stimulations of the mesencephalic trigeminal nucleus. These results suggest that a possible regulatory system involving the dopamine receptor in the uptake and retrograde transport of HRP from axon terminals to cell bodies of the masseteric motoneuron exists in higher order neurons which make synaptic contact with the motoneuron.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopaminérgicos / Antagonistas de Dopamina / Peroxidase do Rábano Silvestre / Músculo Masseter / Neurônios Motores Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 1992 Tipo de documento: Article País de afiliação: Japão
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopaminérgicos / Antagonistas de Dopamina / Peroxidase do Rábano Silvestre / Músculo Masseter / Neurônios Motores Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 1992 Tipo de documento: Article País de afiliação: Japão