Clonal analysis of T-cell responses to the HIV-1 envelope proteins in AIDS vaccine recipients.
AIDS Res Hum Retroviruses
; 8(8): 1349-52, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1361352
ABSTRACT
Both CD4+ and CD8+ CTL responses specific for the HIV-1 envelope proteins can be elicited in seronegative humans by candidate AIDS vaccines. The phenotype of the responding CTL depends upon the nature of the vaccine, with CD8+ CTL being found exclusively in recipients of live virus vaccines. Both types of CTL are active against HIV-1-infected cells in vitro. However, the potential efficacy of vaccine-induced CTL in preventing infection in vaccinated individuals exposed to HIV-1 is unknown and is likely to be dependent upon complex factors including lytic activity against divergent strains, cytokines produced, and the lysis of noninfected CD4+ T cells.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Sintéticas
/
Antígenos HIV
/
Produtos do Gene env
/
Subpopulações de Linfócitos T
/
HIV-1
/
Soropositividade para HIV
/
Vacinas contra a AIDS
Limite:
Humans
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1992
Tipo de documento:
Article