Absence of a direct coupling of a G protein to dihydropyridine binding sites in rat heart.
Biochem Pharmacol
; 44(8): 1680-2, 1992 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-1384505
ABSTRACT
In rat heart membranes, the addition of guanine 5'-O-(3-thiotriphosphate) (GTP-gamma-S), a stable GTP analogue, did not significantly modify the displacement of [3H]PN 200-110 binding by the 1,4-dihydropyridine (DHP) agonist Bay K 8644 and antagonists, nifedipine and nicardipine. These results are in agreement with some previously reported electrophysiological and pharmacological data, and they suggest that there is no direct involvement of a G protein in the modulation of DHP sensitive Ca channels in cardiac cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Di-Hidropiridinas
/
Canais de Cálcio
/
Proteínas de Ligação ao GTP
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França