c-Jun causes focus formation and anchorage-independent growth in culture but is non-tumorigenic.
Oncogene
; 7(10): 2077-80, 1992 Oct.
Article
em En
| MEDLINE
| ID: mdl-1408150
ABSTRACT
The RCAS retroviral vector was used to express chicken and mouse cellular Jun proteins in chicken embryo fibroblasts. Both mouse and chicken proteins induced foci of transformed cells with low to moderate efficiency compared with viral Jun, but were as effective as the viral protein in promoting anchorage-independent growth. Viral Jun and a recombinant between viral and cellular Jun induced tumors in 1-day-old chicks; the cellular Jun proteins were uniformly non-tumorigenic.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Proteínas Proto-Oncogênicas c-jun
/
Neoplasias Experimentais
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Oncogene
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Ano de publicação:
1992
Tipo de documento:
Article