Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion.
Proc Natl Acad Sci U S A
; 89(20): 9739-43, 1992 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-1409691
ABSTRACT
We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Autoanticorpos
/
Autoantígenos
/
Doenças Autoimunes
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RNA de Transferência de Serina
/
Selenocisteína
/
Hepatite Crônica
Limite:
Humans
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Espanha