Clearance of theophylline by hemodialysis in one patient with chronic renal failure.
Chest
; 102(5): 1621-3, 1992 Nov.
Article
em En
| MEDLINE
| ID: mdl-1424911
ABSTRACT
The clearance of theophylline by hemodialysis was determined in one patient who had polycystic kidney with chronic renal failure and bronchial asthma. The serum levels of theophylline were determined by enzymatic immunoassay on two consecutive days, once on a dialysis day and again on a nondialysis day. Clearance of theophylline by hemodialysis was 119 ml/min, and the extraction efficiency was 0.56. The elimination half-life of theophylline shortened from 5.7 h to 1.6 h during hemodialysis. The dialysis rate constant (Kd) was 0.32/h, and 79 percent of the total body store of the drug was removed during a 4-h dialysis. Patients receiving theophylline who are maintained on hemodialysis should be closely monitored for bronchospasm during and after the hemodialysis procedure. Measurement of serum concentrations of theophylline should be employed to facilitate increases in dosage during hemodialysis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Teofilina
/
Diálise Renal
/
Falência Renal Crônica
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Chest
Ano de publicação:
1992
Tipo de documento:
Article