The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice.
Eur J Pharmacol
; 220(1): 107-10, 1992 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-1425976
ABSTRACT
We studied the effects of a selective inhibitor of protein kinase C (PKC), 2,6-diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl]methyl)hexamide (NPC 15437), on acquisition and memory retention of a Y-maze avoidance task in mice. Post-training administration of NPC 15437 (0.1-10 mg/kg i.p.) induced a dose-dependent deficit in retention of the temporal but not the spatial component of the task. This selective amnesia does not reflect state dependence and NPC 15437 (1 mg/kg) had no effect on acquisition and memory retrieval. Our results suggest that this new PKC inhibitor interferes with mechanisms underlying memory consolidation. This is in agreement with recent findings suggesting that PKC is involved in memory processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Proteína Quinase C
/
Amnésia
/
Memória
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França