Acute effects of marijuana on cognition: relationships to chronic effects and smoking techniques.
Pharmacol Biochem Behav
; 43(3): 907-17, 1992 Nov.
Article
em En
| MEDLINE
| ID: mdl-1448485
ABSTRACT
A double-blind, placebo-controlled study assessed acute effects on human cognition of marijuana smoking involving long or short durations of inhalation and breath holding. During eight test sessions, 48 adult, male volunteers completed standardized, pencil-and-paper tests of educational development and ability, as well as computerized tests of learning, associative processes, abstraction, and psychomotor performance. Marijuana impaired all capabilities except abstraction and vocabulary. These impairments were more pervasive than those associated with heavy, chronic marijuana use in a previous study involving the same tests, but showed some similarities. Marijuana altered associative processes, encouraging more uncommon associations. Marijuana-induced impairment in learning pairs of words was influenced by associative relationships between the words. There were a few hints that prolonged breath holding increased marijuana's effects under some test conditions, but in general it did not. Prolonged breath holding itself affected performance in four tests, regardless of whether subjects smoked marijuana or placebo. Whether physiological or psychological factors (e.g., exposure to carbon monoxide in smoke or subjects' expectations) produced these effects could not be determined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fumar Maconha
/
Cognição
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1992
Tipo de documento:
Article