[HLA-G and local placental immunity]. / HLA-G et immunité placentaire locale.
Gynecol Obstet Fertil
; 31(9): 782-5, 2003 Sep.
Article
em Fr
| MEDLINE
| ID: mdl-14499728
ABSTRACT
HLA-G is a non-classical major histocompatibility complex class I gene, exhibiting unique structure and whose tissue distribution is mainly restricted to the placenta. Its function contributes to modulate local placental immunity during pregnancy. Major structural characteristics are as follows a unique promoter region, distinct from the other MHC class I promoters described to date, mRNA alternatively spliced into a variety of membrane-bound isoforms and two major soluble forms. HLA-G expression in the placenta is found mainly in extravillous cytotrophoblast that invade decidual tissue and maternal spiral arteries as well as villous cytotrophoblast (soluble form). Soluble HLA-G1 isoforms might play an important role in the embryonic implantation. HLA-G was also found to induce apoptosis of activated CD8(+) T cells. HLA-G also modulates cytokine secretion of NK cells upon interaction with specific receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Antígenos de Histocompatibilidade Classe I
/
Antígenos HLA
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
Fr
Revista:
Gynecol Obstet Fertil
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França