HBcAg induced T-cell independent anti-HBc production in chronic HBsAg carriers.
Arch Virol Suppl
; 4: 29-35, 1992.
Article
em En
| MEDLINE
| ID: mdl-1450704
ABSTRACT
The capacity of the nucleocapsid protein of HBV to function as a T-cell independent antigen in man was studied. When T-cell depleted B-cell cultures were challenged with E coli-derived HBcAg, anti-HBc production was registered in culture supernatants from the majority of chronic HBsAg carriers in a quiescent stage of disease. In contrast, similarly prepared and stimulated cultures from donors with natural acquired immunity to hepatitis B or HB-susceptible controls were non-responsive. Addition of autologous T-cells effectively restored anti-HBc responsiveness in T-cell depleted B-cell cultures from HB-immune donors, demonstrating the T-cell dependency for anti-HBc induction in natural HBV-infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Hepatite B
/
Anticorpos Anti-Hepatite B
/
Antígenos do Núcleo do Vírus da Hepatite B
Limite:
Humans
Idioma:
En
Revista:
Arch Virol Suppl
Assunto da revista:
VIROLOGIA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Suécia