Differences in maintenance of CD8+ and CD4+ bacteria-specific effector-memory T cell populations.
Eur J Immunol
; 33(10): 2875-85, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14515271
ABSTRACT
Our knowledge about the kinetics and dynamics of complex pathogen-specific CD8(+) T cell responses and the in vivo development of CD8(+) memory T cells has increased substantially over the past years; in comparison, relatively little is known about the CD4(+) T cell compartment. We monitored and directly compared the phenotypical changes of pathogen (Listeria monocytogenes)-specific CD8(+) and CD4(+) T cell responses under conditions leading to effective and long-lasting protective immunity. We found that the general kinetics of bacteria-specific CD8(+) and CD4(+) T cells during the effector and post-effector phases are synchronized. However, later during the memory phase, CD8(+) and CD4(+) T cell populations differ substantially. Whereas CD8(+) memory T cell populations with immediate effector function are readily detectable in lymphoid and non-lymphoid tissues and remain remarkably stable in size, antigen-specific CD4(+) effector-memory T cells decline continuously in frequency over time. These findings have important implications for the better understanding of the in vivo development of protective immunity towards intracellular pathogens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
/
Linfócitos T CD4-Positivos
/
Linfócitos T CD8-Positivos
/
Memória Imunológica
/
Listeria monocytogenes
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Alemanha