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Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event.
Wasserman, R; Galili, N; Ito, Y; Reichard, B A; Shane, S; Rovera, G.
Afiliação
  • Wasserman R; Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania.
J Exp Med ; 176(6): 1577-81, 1992 Dec 01.
Article em En | MEDLINE | ID: mdl-1460419
ABSTRACT
The presence of N sequences in the complementarity determining region 3 (CDR3) of the rearranged immunoglobulin H chain is developmentally regulated N regions are generally present in the DJH joinings of adult B cells but are often absent in fetal B cells. Analysis of the CDR3 in 61 B precursor acute lymphoblastic leukemias indicated that 87.5% of the leukemias obtained from children < or = 3 yr old lacked N regions at the DJH junction. In contrast, in children > 3 yr old, only 11.1% of the leukemias lacked N regions at this junction, a frequency similar to what we have observed in B cells from children and adults. These findings suggest that the majority of leukemias presenting within the first 3 yr of age arise from an in utero transforming event.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina / Região de Junção de Imunoglobulinas / Linfócitos B / Rearranjo Gênico / Cadeias Pesadas de Imunoglobulinas / Leucemia-Linfoma Linfoblástico de Células Precursoras Limite: Adult / Child, preschool / Humans / Infant Idioma: En Revista: J Exp Med Ano de publicação: 1992 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina / Região de Junção de Imunoglobulinas / Linfócitos B / Rearranjo Gênico / Cadeias Pesadas de Imunoglobulinas / Leucemia-Linfoma Linfoblástico de Células Precursoras Limite: Adult / Child, preschool / Humans / Infant Idioma: En Revista: J Exp Med Ano de publicação: 1992 Tipo de documento: Article