Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event.
J Exp Med
; 176(6): 1577-81, 1992 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-1460419
ABSTRACT
The presence of N sequences in the complementarity determining region 3 (CDR3) of the rearranged immunoglobulin H chain is developmentally regulated N regions are generally present in the DJH joinings of adult B cells but are often absent in fetal B cells. Analysis of the CDR3 in 61 B precursor acute lymphoblastic leukemias indicated that 87.5% of the leukemias obtained from children < or = 3 yr old lacked N regions at the DJH junction. In contrast, in children > 3 yr old, only 11.1% of the leukemias lacked N regions at this junction, a frequency similar to what we have observed in B cells from children and adults. These findings suggest that the majority of leukemias presenting within the first 3 yr of age arise from an in utero transforming event.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Região Variável de Imunoglobulina
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Região de Junção de Imunoglobulinas
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Linfócitos B
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Rearranjo Gênico
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Cadeias Pesadas de Imunoglobulinas
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Adult
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Child, preschool
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Humans
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Infant
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1992
Tipo de documento:
Article