Steroids and the reversal of age-associated changes in myelination and remyelination.
Prog Neurobiol
; 71(1): 49-56, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14611867
ABSTRACT
The myelin sheaths that surround all but the smallest diameter axons within the mammalian central nervous system (CNS) must maintain their structural integrity for many years. Like many tissues, however, this function is prone to the effects of ageing, and various structural anomalies become apparent in the aged CNS. Similarly, the regenerative process by which myelin sheaths, lost as a consequence of exposure to a demyelinating insult, are restored (remyelination) is also affected by age. As animals grow older, the efficiency of remyelination progressively declines. In this article, we review both phenomena and describe how both can be partially reversed by steroid hormones and their derivatives.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Envelhecimento
/
Bainha de Mielina
/
Regeneração Nervosa
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Neurobiol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França