[Major histocompatibility complex (MHC) class II: are lipid rafts the missing link?]. / Complexe majeur d'histocompatibilité de classe II : diversité fonctionnelle.
Med Sci (Paris)
; 19(10): 988-93, 2003 Oct.
Article
em Fr
| MEDLINE
| ID: mdl-14613012
ABSTRACT
Aside from their crucial roles in the presentation of nominal antigen to CD4+ T cells and susceptibility to autoimmune diseases, substantial evidences suggest that MHC class II molecules act as signal transducer receptors as well. The signals transmitted affect diverse biological functions. Paradoxically, the cytoplasmic and transmembrane domains of these molecules are devoid of classic signaling motifs. The recent discovery of the presence of membrane microdomains, also called lipid rafts, that are enriched in kinases and adaptor molecules, may contribute to the elucidation of the mechanisms by which MHC class II molecules transmit their signals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Microdomínios da Membrana
Limite:
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Assunto da revista:
MEDICINA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Canadá