Administration of an insulin powder to the lungs of cynomolgus monkeys using a Penn Century insufflator.
Int J Pharm
; 269(2): 523-7, 2004 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-14706262
ABSTRACT
A powder formulation of live-attenuated measles vaccine is being developed for administration to the lungs. The safety and efficacy of the powder will be assessed by insufflation into cynomolgus monkeys. A Penn Century insufflator has been evaluated for powder dosing to the monkeys using an insulin formulation having similar physicochemical characteristics to the vaccine powder. Insulin pharmacokinetics were compared following dosing by powder insufflation, solution instillation into the trachea and subcutaneous injection. The insulin dosed to the lungs and trachea was more rapidly absorbed than that administered subcutaneously. Insulin bioavailability was greater from the inhaled powder than from the instilled solution. The findings confirm that the Penn Century device is suitable for vaccine powder dosing to the deep lung.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insulina
/
Pulmão
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido