Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin.
Dig Dis Sci
; 37(12): 1847-52, 1992 Dec.
Article
em En
| MEDLINE
| ID: mdl-1473433
ABSTRACT
6MNA, the active metabolite of the nonacidic antiinflammatory drug nabumetone, was investigated using intravenous administration for effects on (1) carrageenan paw edema and gastric irritancy compared with either oral nabumetone or both oral and intravenous indomethacin when given acutely and (2) gastrointestinal irritancy when given in repeat dosing studies. Oral doses of nabumetone or intravenous 6MNA produced effective antiinflammatory activity together with significant inhibition of paw exudate PGE2. Antiinflammatory oral doses of nabumetone or intravenous 6MNA produced minimal effects on gastric 6-keto PGF1 alpha production with an absence of gastric damage, in contrast with indomethacin. In repeat dose studies, 6MNA failed to induce gastrointestinal damage even at doses where general toxicity was evident. These results show that in the rat, 6MNA is an effective antiinflammatory drug but even in very high intravenous doses does not have the propensity to induce gastrointestinal damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Butanonas
/
Anti-Inflamatórios não Esteroides
/
Indometacina
/
Sistema Digestório
/
Mucosa Gástrica
/
Ácidos Naftalenoacéticos
Limite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Reino Unido