[Follow-up evaluation of metastatic neuroblastoma using high dose [131I-meta]iodobenzylguanidine]. / Verlaufsbeurteilung des metastasierten Neuroblastoms mittels hochdosiertem [131J-meta]Jodobenzylguanidin.
Nuklearmedizin
; 31(6): 209-12, 1992 Dec.
Article
em De
| MEDLINE
| ID: mdl-1491958
ABSTRACT
Between 1989 and 1990 nine children with neuroblastoma stage IV (according to Evans) have been treated with high-dose [131I-meta]Iodobenzylguanidine (HD-mIBG). The total HD-mIBG dose administered to each child was at mean 699.3 +/- 111 MBq/kg body weight. Prior to (median 28 days) and after (median 50 days) HD-mIBG treatment a diagnostic scan with [123I-meta]Iodobenzylguanidine ([123I-m]IBG) was performed. Scans performed with HD-mIBG were superior to diagnostic scans for the detection of bone lesions in 8/9 children, for the detection of soft tissue lesions in 4/9 children, and for a more precise diagnosis of the primary tumor in 1 child. In 4 children lesions which were primarily identified in the therapeutic scan could be further observed in posttherapeutical examinations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos do Iodo
/
Iodobenzenos
/
Neuroblastoma
/
Antineoplásicos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
De
Revista:
Nuklearmedizin
Ano de publicação:
1992
Tipo de documento:
Article